美研留學(xué)西北大學(xué)博士后項目申請介紹

Northwestern University西北大學(xué)創(chuàng)立于1851年，一所私立研究型大學(xué)，坐落于美國伊利諾伊州東北部城市埃文斯頓，十大聯(lián)盟創(chuàng)始成員和美國大學(xué)協(xié)會成員。西北大學(xué)由John Evans先生創(chuàng)辦于1851年，其主校區(qū)位于伊利諾伊州埃文斯頓市郊的密歇根湖湖畔，臨近美國第三大城市芝加哥。西北大學(xué)醫(yī)學(xué)院坐落在繁華的芝加哥市中心，始建于1926年的醫(yī)學(xué)院大樓Ward Memorial Building是美國第一座學(xué)術(shù)摩天樓。2022USNews世界排名24。美國西北大學(xué)

優(yōu)勢專業(yè)

農(nóng)業(yè)及生物工程、人類學(xué)、應(yīng)用經(jīng)濟及商業(yè)管理、考古學(xué)、建筑、亞洲研究、天文學(xué)、生物科學(xué)、生物及社會、化學(xué)工程、化學(xué)、土木及環(huán)境工程等。

成績要求GAp3.54

語言要求托福109

美國西北大學(xué)博士后職位招聘

We are looking for two talented and energetic postdoctoral fellows to join Dr.Yan Liu’s laboratory(https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=50632)at the Northwestern University Feinberg School of Medicine and Robert H.Lurie Comprehensive Cancer Center,located in Chicago,IL.These positions are fully funded for multiple years.

The Liu laboratory is interested in investigating the molecular mechanisms governing normal and malignant hematopoiesis,with an emphasis on understanding hematopoietic stem cell(HSC)self-renewal and pathogenesis of myeloid malignancies,including clonal hematopoiesis of indeterminate potential(CHIp),myelodysplastic syndromes(MDS)and acute myeloid leukemia(AML).Our long-term goals are to identify novel regulators of HSC self-renewal,understand the molecular mechanisms regulating their function,and develop novel therapeutic strategies to eliminate leukemia stem cells(LSCs)and improve leukemia treatment.

One of the projects in the Liu lab is to determine the role of tumor suppressor p53 in leukemogenesis and treatment.Our studies have led to multiple recent manuscripts,including two manuscripts currently in revision(Vemula et al.,Cancer Discovery,2022;and Chen et al.,Cancer Cell,2022).

1.Liu,Y.,Elf,S.E.,Miyata,Y.,Sashida,G.,Liu,Y.H.,Huang,G.,Di Giandomenico,S.,Lee,J.M.,Deblasio,A.,Menendez,S.,Antipin,J.,Reva,B.,Koff,A.and Nimer,S.D.p53 Regulates Hematopoietic Stem Cell Quiescence.Cell Stem Cell,2009;4(1):37-48.pMCID:pMC2839936.

2.Chen,S.,Gao,R.,Yao,C.,Kobayashi,M.,Liu,S.Z.,Yoder,M.C.,Broxmeyer,H.,Kapur,R.,Boswell,H.S.,Mayo,L.D.,and Liu,Y.Genotoxic stresses promote the clonal expansion of hematopoietic stem cells expressing mutant p53.Leukemia,2018 Mar;32(3):850-854.pMCID:pMC5842141

3.Nabinger,S.,Chen,S.,Yao,C.,Gao,R.,Kobayashi,M.,Vemula,S.,Fahey,A.C.,Wang,C.,Daniels,C.,Boswell,H.S.,Sandusky,G.E.,Mayo,L.D.,Kapur,R.,and Liu,Y.Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development.Leukemia,2019 Jun;33(6):1535-1539.pMID:30675010

4.Chen,S.,Wang,Q.,Yu,H.,Capitano,M.L.,Vemula,S.,Nabinger,S.C.,Gao,R.,Yao,C.,Kobayashi,M.,Geng,Z.,Fahey,A.,Henley,D.,Liu,S.Z.,Wolf,E.R.,Ramdas,B,Cai,Z.,Gao,H.,Luo,N.,Sun,Y.,Wong,T.N.,link,D.C.,Liu,Y.,Boswell,H.S.,Mayo,L.D.,Huang,G,Kapur,R.,Yoder,M.C.,Broxmeyer,H.E.,Gao,Z.,and Liu,Y.Mutant p53 Drives Clonal Hematopoiesis through Modulating Epigenetic pathway.Nature Communications,2019 Dec 11;10(1):5649.doi:10.1038/s41467-019-13542-2.pMID:31827082

The first postdoctoral fellow will determine the impact of mutant p53 proteins on transcription,chromatin accessibility,histone modifications,and 3D chromatin structure in hematopoietic stem cells and leukemia stem cells.

The second postdoctoral fellow will develop novel therapeutic approaches,including small molecule inhibitors and CAR-T therapy,for leukemia patients with p53 mutations.

Successful candidates should be highly motivated and have a recent ph.D.degree with a background in molecular biology,biochemistry,epigenetics,and cancer research.

Applicants should have a strong publication record,creative thinking,effective oral and written communication skills,good team spirit,and a willingness to learn new techniques and approaches.

preference will be given to candidates with strong first-author publications in high-impact peer-reviewed journals.西北大學(xué)博士

美研留學(xué)西北大學(xué)博士后項目申請介紹

WHO WE ARE

We utilize molecular,genetic,immunological,biochemical,and pharmacological approaches as well as unbiased genome wide studies,including RNA-seq,ChIp-seq,ATAC-seq,HiC,whole genome sequencing,CRISpR-Cas9-mediated screening in mammalian cells as well as proteomics studies,to investigate the molecular basis of HSC self-renewal and leukemogenesis.Specific relevant techniques include analysis of DNA,RNA,and proteins,flow cytometry,and experience with murine models and bone marrow samples from patients.

WHERE WE ARE

Our lab is on the fifth floor of the Robert H.Lurie Medical Research Center of Northwestern University in Chicago,IL,which is home to many of the elite biomedical researchers at Northwestern.The Lurie Center and the rest of the Northwestern University Feinberg School of Medicine is located in the heart of Chicago’s Magnificent Mile,blocks away from beautiful Lake Michigan.

Interested candidates should send the following items to Dr.Yan Liu(yan.liu northwestern.edu)

A one--page cover letter describing areas of research interests and career goals

Curriculum vitae with bibliography

Contact information for 3 references

*Northwestern University is an Equal Opportunity,Affirmative Action Employer of all protected classes,including veterans and individuals with disabilities.Women,racial and ethnic minorities,individuals with disabilities,and veterans are encouraged to apply.Hiring is contingent upon eligibility to work in the United States.

在美國，西北大學(xué)是人人皆知的名牌大學(xué)。該校創(chuàng)建于十九世紀，至今已有一百多年的歷史。西北大學(xué)商學(xué)院，從1988年至1994年，六年蟬聯(lián)美國各名牌大學(xué)商學(xué)院的排名第一位。西北大學(xué)位于美國伊利諾伊州的小鎮(zhèn)埃文斯通。是莘莘學(xué)子們爭相報考的學(xué)院，它招收嚴格，只錄取最優(yōu)秀的人才入內(nèi)深造。西北大學(xué)的其他學(xué)院和專業(yè)也都大名鼎鼎，1998年的諾貝爾獎金獲得者中，就有兩位是西北大學(xué)的人。一位是諾貝爾化學(xué)獎的得主之一波普爾，他是西北大學(xué)的教授；另一位是諾貝爾醫(yī)學(xué)獎的得主之一、八十二歲的羅伯特·弗奇戈特教授，他是西北大學(xué)的畢業(yè)生在西北大學(xué)獲得生物化學(xué)博士學(xué)位。美國碩士博士

西北大學(xué)這所被認為在中西部最為精英的頂級大學(xué)，是美國十大名校聯(lián)盟中唯一的一所私立學(xué)校。雖不是常青藤聯(lián)盟的成員，但比起在美國東部地區(qū)同等級的學(xué)校來說更專注于教學(xué)的實用性。與它鄰近的競爭者芝加哥大學(xué)，以及除賓大外的所有常青藤學(xué)院相比，西北大學(xué)的教育更具有職業(yè)導(dǎo)向性。

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